Synthesis of chloroform

Preparation of chloroform

Preparation of trichloromethane (chloroform)

Preparation of chloroform (chloroform)

200 g of fresh bleaching powder are ground up to a thin paste with 800 ml of water. The mixture is transferred to a large flask fitted with a distillation condenser and receiving flask. 40 g of acetone or ethanol are then added and the reaction mixture is cautiously heated until the reaction sets in. Th chloroform is removed by distillation and the distillate is washed with dilute solution of sodium hydroxide, dried over calcium chloride, and then redistilled. Chloroform is a heavy colorless liquid with a sweet smell boiling point 61° C. Yield about 40 g.

Preparation of organic compounds, E. de. Barry Barnett, 78, 1912

Preparation of chloroform is presented in the following video by Doug’s Lab.

Preparation of chloroform by electrolytic process

A 20 % solution of sodium chloride is heated at 100° C and is stirred. As anode a carbon spatulas is used and 5-6 amp. current is passed. Acetone through the pipe is introduced into the bottom of the flask and is acted upon by the chlorine, forming a compound intermediate chlorinated compound which is decomposed by the action of the sodium hydroxide produced, giving chloroform. The yield of chloroform is 85 % of the theoretical.

Organic medical chemicals, by M. Barrowliff, 23, 1921

Rev. d. Prod. Chim. 3 309





InChI Key


Canonical SMILES


MeSH Synonyms

Chloroform, chloroform

Depositor-Supplied Synonyms

CHLOROFORM, chloroform, Trichloroform, Formyl trichloride, Methenyl trichloride, Methane, trichloro-, Methyl trichloride, Methane trichloride, 67-66-3, Trichlormethan, Chloroforme, Cloroformio, Triclorometano, RCRA waste number U044, Freon 20, Trichloormethaan, NCI-C02686, R 20 (Refrigerant), CHCl3, Methylidyne trichloride, 1,1,1-chloroform, Methenyl chloride, Refrigerant R20, Chloroforme [French], R 20, Caswell No. 192, Cloroformio [Italian], Trichlormethan [Czech], Trichloormethaan [Dutch], Triclorometano [Italian], NSC 77361, RCRA waste no. U044, HSDB 56, CCRIS 137, UNII-7V31YC746X, CHEBI:35255, Chloroform [UN1888] [Poison], HEDRZPFGACZZDS-UHFFFAOYSA-N, Chloroform solution, EINECS 200-663-8, UN1888, EPA Pesticide Chemical Code 020701, BRN 1731042, NCGC00090794-01, AI3-24207, CHLOROFORMWith Amylene, CHLOROFORMWith Ethanol, DSSTox_CID_306, DSSTox_RID_75501, DSSTox_GSID_20306, CAS-67-66-3, cloroform, chloro form, chloro-form, Chloroform-, trichloro-methane, trichloro- methane, methane trichloride, tris(chloranyl)methane, CHLOROFORM, ACS, Chloroform [NF XVII], chloroformium pro narcosi, WLN: GYGG, EyAE(1/4)xIe, AC1L1M1C, 48520U_SUPELCO, KSC353S7H, 40021_SUPELCO, 48603_SUPELCO, C2432_SIGMA, C7559_SIGMA, CHEMBL44618, 132950_ALDRICH, 24216_RIEDEL, 288306_ALDRICH, 32211_RIEDEL, 32286_RIEDEL, 372978_ALDRICH, 487163_ALDRICH, 487171_ALDRICH, 487759_ALDRICH, 496189_ALDRICH, 611743_ALDRICH, 611778_ALDRICH, 611786_ALDRICH, 611859_ALDRICH, 612448_ALDRICH, 613037_ALDRICH, 613304_ALDRICH, 613312_ALDRICH, 650471_ALDRICH, 650498_ALDRICH, 676888_ALDRICH, AC1Q3H37, C2432_SIAL, GTPL2503, 02487_FLUKA, 25669_FLUKA, 25670_FLUKA, 25690_FLUKA, CTK2F3973, 487163_FLUKA, 487171_FLUKA, 487759_FLUKA, 611743_FLUKA, 611778_FLUKA, 611786_FLUKA, 611859_FLUKA, 612448_FLUKA, 613037_FLUKA, 613304_FLUKA, 613312_FLUKA, MolPort-000-871-941, 24216_SIAL, 25690_SIAL, 32211_SIAL, 32286_SIAL, 34854_SIAL, 7V31YC746X, LTBB002580, 132950_SIAL, 288306_SIAL, 319988_SIAL, 366919_SIAL, 366927_SIAL, 372978_SIAL, 439142_SIAL, 443573_SIAL, 472468_SIAL, 472476_SIAL, 480150_SIAL, 496189_SIAL, 650471_SIAL, 650498_SIAL, 676888_SIAL, Chloroform, 99.8%, ACS Reagent, NSC77361, Tox21_111024, Tox21_202494, NSC-77361, AKOS000269026, InChI=1/CHCl3/c2-1(3)4/h1, LS-1567, RL04584, RTR-022720, UN 1888, Freon 20, R-20, UN 1888, NCGC00090794-02, NCGC00260043-01, AN-41895, F 20, TR-022720, C0819, FT-0645128, S0626, C13827, WATER DISINFECTION BYPRODUCTS(CHLOROFORM), 300037X, 300040X, 4-01-00-00042 (Beilstein Handbook Reference), A835850, L023971, 3B4-0472, BRD-K88785477-001-01-8, I14-111606, 8013-54-5

Removed Synonyms

CID6212, c0175, c0595, c1111, D002725, TCM, 31717-44-9, CF, MCH, TCE

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1 comment

  1. Fritz Haber

    2-propanol may also be used insted of acetone in the first procedure. For this, a larger amount of the hypochlorite is required as the 2-propanol is first oxidized to 2-propanone.

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