Synthesis of p-xylene

Preparation of p-xylene

Alternative Names: P-XYLENE; 1,4-Dimethylbenzene; Para-Xylene; 1,4-Xylene; P-Methyltoluene; P-Dimethylbenzene;

Preparation of p-xylene

Preparation of p-xylene

The Grignard reagent is prepared, by heating 67 g p-bromotoluene, 10 g of dry magnesium and 200 ml of anhydrous ether. When almost all the magnesium has disappeared a solution of 50 g of dimethyl sulfate in anhydrous ether is added. A vigorous reaction takes place, and after it subsides the reaction product is poured on to ice. The ether is removed by distillation, and the residue is steam distilled. The oil is separated from the distillate and fractionated, the fraction, 136-140° C, being collected. Yield 75% theoretical (30 g). Colorless oil: characteristic odor; b.p. 138 ° C; d=0.869 g/ml.

Systematic organic chemistry, by W. M. Cumming, 68, 1937.





InChI Key


Canonical SMILES


MeSH Synonyms

4-xylene, p-xylene, p-xylol, para-xylene, paraxylene

Depositor-Supplied Synonyms

P-XYLENE, 1,4-Dimethylbenzene, Para-Xylene, 1,4-Xylene, p-Methyltoluene, p-Dimethylbenzene, p-Xylol, 106-42-3, Benzene, 1,4-dimethyl-, 4-Xylene, Chromar, 4-Methyltoluene, Scintillar, Xylene, p-isomer, Xylene, p-, 1,4-Dimethylbenzol, Benzene, p-dimethyl-, NSC 72419, UNII-6WAC1O477V, CCRIS 910, CHEMBL31561, HSDB 136, CHEBI:27417, URLKBWYHVLBVBO-UHFFFAOYSA-N, 1,4-Dimethylcyclohexane, mixture of cis and trans, EINECS 203-396-5, AI3-52255, p-Xylene-13C8, paraxylene, PXY, Solvent xylene, p-Xylenes, 1,4-dimethyl benzene, ACMC-1BROJ, AC1L1PLL, AC1Q2QRE, DSSTox_CID_1868, bmse000834, p-XYLENE- D10, DSSTox_RID_76374, DSSTox_GSID_21868, ScintiLene™ Cocktail, KSC175S8L, 48583_SUPELCO, BENZENE,1,4-DIMETHYL, 134449_ALDRICH, 296333_ALDRICH, 317195_ALDRICH, 6WAC1O477V, WLN: 1R D1, 95680_FLUKA, 95682_FLUKA, CTK0H5985, 187l, METHYL,(4-METHYLPHENYL)-, MolPort-001-783-900, 95682_SIAL, LABOTEST-BB LTBB002309, LTBB002309, ZINC968254, Benzene, 1,4-dimethyl-, oxidized, 134449_SIAL, 296333_SIAL, 317195_SIAL, NSC72419, Tox21_201113, ANW-15345, AR-1L2588, BDBM50008567, LS-397, NSC-72419, STL264212, ZINC00968254, AKOS000121124, AS00254, DB03463, MCULE-3769448716, RL01514, RP18866, TRA0007876, NCGC00091661-01, NCGC00091661-02, NCGC00258665-01, p-Xylene [UN1307] [Flammable liquid], AN-22433, Aromatic hydrocarbons, C8, o-xylene-lean, CAS-106-42-3, CJ-04643, OR000302, OR198617, OR198618, OR245569, OR271024, ZB015532, p-Xylene [UN1307] [Flammable liquid], TC-104090, TR-001252, FT-0689271, S0649, A18069, C06756, 28306-EP2270003A1, 28306-EP2277867A2, 28306-EP2280003A2, 28306-EP2289896A1, 28306-EP2301918A1, 28306-EP2305825A1, 28306-EP2309584A1, 28306-EP2314577A1, 28306-EP2380568A1, 3B4-1122, I01-9720, InChI=1/C8H10/c1-7-3-5-8(2)6-4-7/h3-6H,1-2H, 68411-39-2, 68650-36-2

Removed Synonyms

Xylene, Benzene,4-dimethyl-, 1-methylnaphthalen-2-ol, 1-Methyl-2-Naphthalenol, UN 1307 (Related), CID7809, UN1307, c0083, ‘LGC’ (2031), X0014, X0044, C031286, 589-90-2, 1076-26-2, 1330-20-7, 41051-88-1

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