Synthesis of methyl succinate

Preparation of methyl succinate

Preparation of methyl succinate

Preparation of methyl succinate

10 g of succinic anhydride are refluxed with 10 g of pure anhydrous methyl alcohol for 1 hour, the excess of methyl alcohol is removed under reduced pressure at ordinary temperature, and the residue recrystallised from hot carbon disulphide. The yield of methyl succinate is most theoretical, Glistening plates, insoluble in water; m.p. 57° C; b.p. 151° C/20 mm.

Systematic organic chemistry, by W. M. Cumming, 259, 1937.


4-methoxy-4-oxobutanoic acid



InChI Key


Canonical SMILES


MeSH Synonyms

3H-methylsuccinate, DL-methylsuccinate, methyl succinate, monomethyl succinate, monomethyl succinate sodium salt, succinic acid monomethyl ester

Depositor-Supplied Synonyms

4-Methoxy-4-oxobutanoic acid, 3878-55-5, Monomethyl succinate, Succinic acid monomethyl ester, Methyl hydrogen succinate, Mono-Methyl Succinate, Butanedioic acid, monomethyl ester, 3-Carbomethoxypropanoic acid, mono-Methyl hydrogen succinate, Succinic acid, monomethyl ester, Butanedioic acid, 1-methyl ester, UNII-YA2V724S0A, butanedioic acid monomethyl ester, 3-(methoxycarbonyl)propanoic acid, JDRMYOQETPMYQX-UHFFFAOYSA-N, SBB061270, Butanedioic acid, methyl ester, Succinic acid 1-methyl, Substrate analogue, 10, AC1Q5VRX, AC1L2T5M, DSSTox_CID_24425, DSSTox_RID_80218, DSSTox_GSID_44425, M81101_ALDRICH, succinic acid 4-methyl ester, SCHEMBL164072, 3-methoxycarbonylpropionic acid, 4-methoxy-4-oxo-butanoic acid, ARONIS006766, NSC511, YA2V724S0A, butanedioic acid 1-methyl ester, 14193_FLUKA, 4-Methoxy-4-oxobutanoic acid #, BDBM82193, CHEBI:75146, CTK3J0108, JDRMYOQETPMYQX-UHFFFAOYSA-, NSC 511, NSC-511, MolPort-000-141-742, 4-(methyloxy)-4-oxobutanoic acid, ZINC152993, AC1Q4421, AC1Q4422, ACN-S001857, ACN-S004259, EBD25820, EINECS 223-408-2, Tox21_302188, AR-1G3095, STL068961, AKOS000264979, MCULE-4083173324, MP-0271, RP00962, Succinic acid, monomethyl ester (8CI), NCGC00257549-01, AJ-12868, AK-47290, AN-24905, BR-47290, M928, OR025512, OR265725, CAS-3878-55-5, AI3-03389, KB-193098, AM20100028, BB 0254379, ST45043530, AZ0001-0177, EN300-24949, I04-0309, T5957915, 3B3-032900, InChI=1/C5H8O4/c1-9-5(8)3-2-4(6)7/h2-3H2,1H3,(H,6,7)

Removed Synonyms

Methyl succinate, monomethylsuccinate, DL-methylsuccinate, 3H-methylsuccinate, monomethyl succinate sodium salt, CID77487, C041105, 77341-67-4, 81809-88-3

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