Synthesis of isobutylcyanamide

Preparation of isobutylcyanamide

Preparation of isobutylcyanamide

Preparation of isobutylcyanamide

To a solution of cyanogen bromide (10.0 g, 94mmol) in anhydrous ether (200 ml) was added dropwise 2.2 eq of the isobutylamine in anhydrous ether (100 ml) at — 5° C. The mixture was stirred for 1 hour under a nitrogen atmosphere at the same temperature, then the precipitate (isobutylamine hydrobromide) was filtered off, and the filtrate was concentrated in vacuo below 15 °C. The isobutylcyanamide is unstable and should be used without purification.

Chem. Pharm. Bull. 1996, 44, 2314-2317.

IUPAC Name

2-methylpropylcyanamide

InChI

InChI=1S/C5H10N2/c1-5(2)3-7-4-6/h5,7H,3H2,1-2H3

InChI Key

OMGNVIJEQKWIHI-UHFFFAOYSA-N

Canonical SMILES

CC(C)CNC#N

Depositor-Supplied Synonyms

Isobutylcyanamide, AKOS011769871

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