Synthesis of chlorodiphenylacetic acid

Preparation of chlorodiphenylacetic acid

20 g of hydroxy(diphenyl)acetic acid, are gently warmed with an 20 g of phosphorus oxychloride until the acid goes into solution and a red color begins to make its appearance. The reaction mixture is allowed to cool and the crystalline crude mass thus obtained shaken with a 1000 ml of cold water for 1-2 hours until the chlorodiphenylacetic acid has become solid. Chlorodiphenylacetic is then collected, washed with water, dried, and recrystallized from a mixture of benzene and ligroin forming colorless rhombic tablets with melting point 118-119 ° C with decomposition. Yield 65 %.

Preparation of organic compounds, E. de. Barry Barnett, 63, 1912


2-chloro-2,2-diphenylacetic acid



InChI Key


Canonical SMILES


Depositor-Supplied Synonyms

Chlorodiphenylacetic acid, chloro(diphenyl)acetic acid, NSC400464, 7475-56-1, NSC-400464, AC1Q3GFC, AC1L32IL, NCIStruc1_000674, NCIStruc2_001221, SCHEMBL41202, CHEMBL1741929, CTK5E0457, 2-chloro-2,2-diphenylacetic acid, EINECS 231-277-8, AR-1I1985, CCG-37810, NCGC00014889, NCI400464, AKOS003601272, Benzeneacetic acid, a-chloro-a-phenyl-, NCGC00014889-02, NCGC00097990-01, NCI60_003739

Removed Synonyms

CID81990, 78-43-3

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