Synthesis of ammonium chloride

Preparation of ammonium chloride

Ammonium chloride may be readily preparared from pure diluted hydrochloric acid and pure ammonium hydroxide:

Preparation of ammonium chloride

Preparation of ammonium chloride

One part of ammonium hydroxide is gradually added to the 2 parts of hydrochloric acid with constant stirring. The solution is evaporated until crystallization of NH4Cl appears, cooled to room temperature and dried. To obtain very pure NH4Cl 200 g of crude ammonium chloride is dissolved in the 300 ml of boiling water. To this solution 10 g of chlorine water and the solution is heated for 20 minutes with proper stirring. Finally 10 g of 10% ammonium hydroxide is added and boiling continued for a few minutes. The solution of ammonium chloride is filtered, evaporated to granulation and dried thoroughly. Pure ammonium chloride is a colorless crystalline, or a white, granular salt. It is soluble in 3 parts of water of 15°, and in its own weight of boiling water. Nearly insoluble in alcohol. Decomposes to ammonia and hydrochloric acid when strongly heated:

Decomposition of ammonium chloride

Decomposition of ammonium chloride

Laboratory manual of inorganic and pharmaceutical preparations, by O. Miner, 14-15, 1911





InChI Key


Canonical SMILES


MeSH Synonyms

Ammoniac, Sal, Ammonium Chloride, Chloride, Ammonium, Sal Ammoniac

Depositor-Supplied Synonyms

AMMONIUM CHLORIDE, Salmiac, 12125-02-9, Sal ammoniac, Amchlor, Ammoneric, Darammon, Ammonium muriate, Ammonium chloride ((NH4)Cl), Ammonchlor, Ammoniumchlorid, Ammoniumklorid, Chlorammonic, Elektrolyt, Salammonite, Chloramon, Sal ammonia, Ammon Chlor, Ammonii Chloridum, Ammonium Chloratum, Cloruro de Amonio, Muriate of Ammonia, Gen-Diur (Spain), Ammonium chloride fume, NH4Cl, Chlorammonic [France], Chlorid amonny [Czech], Ammoniumchlorid [German], Chlorid ammonia [Czech], Ammonium Chloride Tablets, Ammonium Chloride Injection, ammoniumchloride, UNII-01Q9PC255D, azanium chloride, CCRIS 7262, HSDB 483, Ammonium solution, CHEBI:31206, EINECS 235-186-4, AI3-08937, Ammonium chloride solution, Ammonium ion standard solution, 89485-85-8, Filling solution for sodium electrode (2M NH4Cl), azaniumchloride, nushadir salc, salt armoniack, Chlorid ammonia, sal armagnac, Chlorid amonny, ammonium-chloride, ammoniurn chloride, arnmonium chloride, ammonia hydrochloride, Conclyte-A (TN), ammonia hydrochloride-, AC1LAQTK, ACMC-1BSL5, Ammonium chloride [USAN], Ammonium chloride 2.14%, AC1Q1RS4, KSC174K8R, A0171_SIGMA, A9434_SIGMA, Ammonium chloride (JAN/USP), Ammonium chloride [USP:JAN], 11209_RIEDEL, 254134_ALDRICH, 31107_RIEDEL, 318639_ALDRICH, 326372_ALDRICH, 443093_ALDRICH, A4514_SIAL, AC1L199C, CHEMBL1200939, 09677_FLUKA, 09683_FLUKA, 09685_FLUKA, 09718_FLUKA, 09725_FLUKA, CTK0H4588, 318639_FLUKA, 443093_FLUKA, MolPort-003-925-655, NLXLAEXVIDQMFP-UHFFFAOYSA-N, 01Q9PC255D, 11209_SIAL, 31107_SIAL, Ammonium chloride (NH4)(HCl2)), 12125-02-9 (Parent), 213330_SIAL, Ammonium chloride in plastic container, AKOS015833109, LS-3167, RL00918, RTR-003480, 54450-56-5 ((ammonium)HCl2)), Ammonium chloride 0.9% in normal saline, AK115754, E510, KB-250659, TR-003480, FT-0622314, C12538, D01139, 3B4-1953, 1260366-18-4, 127634-24-6, 128532-42-3, 154383-48-9, 15630-61-2, 20548-08-7, 50295-88-0, 54450-56-5, 55871-05-1, 75944-36-4, 867060-75-1, 89485-84-7

Removed Synonyms

PV Tussin Syrup, Mixture Name, Ammoniac, Sal, Chloride, Ammonium, [NH4]Cl, CID25517, A2037, D000643, 12015-14-4

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