Preparation of acetyl cyanide (pyruvonitrile)
For the preparation of acetyl cyanide copper(I) cyanide is prepared by adding potassium cyanide in portions to copper(II) sulfate 5-hydrate with cooling and vigorous stirring. The copper cyanide is filtered off, washed thoroughly, and dried in a thermostat at 60-70° C. Acetyl bromide (1 mole) is added to copper cyanide (1 mole), which causes ebullition; no solvent is used. The mixture is heated under reflux for 1.5-2 hours, then acetyl cyanide formed is separated from copper(I) bromide by distillation. Acetyl cyanide boils at 93° C, the yield is 85-87%.
Angew. Chem. Int. Ed., Engl, 4, 583, 1965.
Pyruvonitrile, Acetyl cyanide, Oxopropionitrile, 2-Oxopropionitrile, 631-57-2, Oxypropionitrile, Propanenitrile, 2-oxo-, 2-Oxopropiononitrile, Pyruvic acid nitrile, .alpha.-Oxopropionitrile, QLDHWVVRQCGZLE-UHFFFAOYSA-N, NSC91482, ACETYLCYANIDE, ACMC-20ajsw, AC1L2BUQ, AC1Q4QFW, CH3C(O)CN, UNII-ULO441649V, 269212_ALDRICH, Propanenitrile, 2-oxo-(9CI), 16000_FLUKA, CTK5B7838, ULO441649V, EINECS 211-159-2, AR-1K9435, NSC-91482, AKOS015900162, SC-51001, AI3-28761, TX-017946, InChI=1/C3H3NO/c1-3(5)2-4/h1H, I14-10193
2-Oxopropanenitrile, CID69430, 6967-21-1