Synthesis of 4′-chloroacetanilide

Preparation of 4′-chloroacetanilide

Preparation of 4'-chloroacetanilide

Preparation of 4′-chloroacetanilide

5 g of acetanilide are dissolved with gentle warming in a mixture of 10 g of glacial acetic acid and 10 g of ethyl alcohol. The solution is then diluted with 100 ml of water and heated to 50° C. At this temperature 100 ml of a cold, 10 %, solution of bleaching powder are slowly added with continual stirring. The 4′-chloroacetanilide is collected, washed with water, and recrystallized from alcohol or dilute acetic acid. 4′-chloroacetanilide colorless needles with melting point 172.5° C.

Preparation of organic compounds, E. de. Barry Barnett, 61, 1912





InChI Key


Canonical SMILES


MeSH Synonyms

4-chloroacetanilide, p-chloroacetanilide

Depositor-Supplied Synonyms

4′-Chloroacetanilide, N-(4-Chlorophenyl)acetamide, 4-Chloroacetanilide, 539-03-7, P-CHLOROACETANILIDE, N-Acetyl-p-chloroaniline, Acetanilide, 4′-chloro-, Acetamide, N-(4-chlorophenyl)-, Acetic-4-chloroanilide, N-(p-Chlorophenyl)acetamide, N-(4-Chloro-phenyl)-acetamide, NSC 40563, Acetic acid 4-chloroanilide, UNII-6I0LI34G5J, HSDB 1410, CHEBI:116915, GGUOCFNAWIODMF-UHFFFAOYSA-N, EINECS 208-707-8, SBB058218, BRN 0509638, Acetic acid, amide, N(4-chlorophenyl)-, AI3-00509, p-Chloroacetoanilide, Acet-p-chloroanilide, ACMC-209las, N-Acetyl-4-chloroaniline, AC1L1W4N, Acetic acid-4-chloroanilide, CHEMBL15991, N-(4-chlorophenyl)-acetamide, SCHEMBL197282, 158631_ALDRICH, 6I0LI34G5J, NSC444, 22810_FLUKA, CTK3J0300, NSC-444, MolPort-001-768-372, 4′-CHLOROACETANILIDE IMP J, NSC40563, STR03412, ANW-31874, BBL034618, LABOTEST-BB LT00792311, LABOTEST-BB LT03331190, NSC-40563, STL419470, ZINC00156872, AKOS003868583, AS02675, MCULE-5567013952, PS-5125, RTR-019043, VZ36750, AJ-13899, AK158951, AN-21316, KB-38170, LS-10533, U438, KB-107447, ST2407389, TR-019043, 4CH-001866, FT-0618154, ST50406697, AZ0001-0034, EN300-79800, 10.14272/GGUOCFNAWIODMF-UHFFFAOYSA-N, C14494, K-9738, 4-12-00-01178 (Beilstein Handbook Reference), AE-562/40197438, doi:10.14272/GGUOCFNAWIODMF-UHFFFAOYSA-N, I01-7201, SR-03000001158-1, InChI=1/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11

Removed Synonyms

CID10871, c0089, A7830

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