Synthesis of 3,4-dichlorobenzoic acid

Preparation of 3,4-dichlorobenzoic acid

10 g of para-chlorbenzoic acid and 75 g antimony pentachloride are heated in a sealed tube to 200° C for 8 hours. After cooling, the tube is opened and the reaction mixture is treated with excess of dilute hydrochloric acid. The precipitated 3,4-dichlorobenzoic acid is collected, washed with cold water, and dissolved in dilute ammonium hydroxide solution. After filtration the solution is evaporated to dryness and the ammonium salt of 3,4-dichlorobenzoic acid decomposed with dilute hydrochloric acid. The acid is collected, washed, and dried. 3,4-dichlorobenzoic acid is recrystallized from dilute alcohol and forms colorless crystals melting at 201-202° C.

Preparation of organic compounds, E. de. Barry Barnett, 59, 1912


3,4-dichlorobenzoic acid



InChI Key


Canonical SMILES


MeSH Synonyms

3,4-dichlorobenzoic acid, 3,4-dichlorobenzoic acid, potassium salt

Depositor-Supplied Synonyms

3,4-DICHLOROBENZOIC ACID, 51-44-5, Benzoic acid, 3,4-dichloro-, 3,4-Dichloro-benzoic acid, UNII-YS4ZR9BXWX, CHEBI:49401, VPHHJAOJUJHJKD-UHFFFAOYSA-N, EINECS 200-099-2, NSC 17583, SBB063116, BRN 2044777, AI3-04213, Benzoic acid,4-dichloro-, WLN: QVR CG DG, 34Z, NSC17583, PubChem3686, ACMC-209kts, YS4ZR9BXWX, 3,4-Dichlorobenzoicacid, AC1Q3MXQ, DSSTox_CID_4980, AC1L1L7E, DSSTox_RID_77609, DSSTox_GSID_24980, Benzoicacid, 3,4-dichloro-, KSC272C0B, AKOS AKM01129, CHEMBL21015, SCHEMBL371998, 144932_ALDRICH, 3,4-DCBA, 36571_RIEDEL, AC1Q72Z9, RARECHEM AL BO 0329, 36571_FLUKA, CTK1H2100, MolPort-001-770-877, OTAVA-BB 1051719, BENZOIC ACID,3,4-DICHLORO, NSC34414, Tox21_200322, ANW-31262, AR-1E9079, LS-157, NSC-17583, NSC-34414, STL168893, AKOS000119790, AC-2437, AS00789, MCULE-8161439486, RP25050, RTR-018321, CAS-51-44-5, NCGC00091648-01, NCGC00091648-02, NCGC00257876-01, AJ-20520, AK-46631, AN-13950, BR-46631, H296, KB-28182, DB-051963, ST2410249, TR-018321, AM20050124, BB 0221129, D0340, FT-0614231, ST50406564, M-5924, AE-562/43459830, I01-0390, 3B3-026401, InChI=1/C7H4Cl2O2/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3H,(H,10,11

Removed Synonyms

Synstigmine, Syntostigmin, Vagostigmin, 3,4-dichlorobenzoate, CID5817, 4-09-00-01006 (Beilstein Handbook Reference), 52645-97-3


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