Synthesis of 2-nitrobenzyl chloride

Preparation of 2-nitrobenzyl chloride

Preparation of 2-nitrobenzyl chloride

Preparation of 2-nitrobenzyl chloride

To the round bottom flask 5 g of orto-nitrobenzyl alcohol are dissolved in 50 g of dry chloroform. The flask is cooled with ice-water and 3 g of powdered phosphorus pentachloride are slowly added. The reaction mixture is left in cold water until the reaction is complete. Chloroform layer is collected, and removed by distillation. Crude 2-nitrobenzyl chloride is a mass of pale yellow needles which melt at 49° C, which is purified by crystallization from chloroform.

Preparation of organic compounds, E. de. Barry Barnett, 66, 1912





InChI Key


Canonical SMILES


Depositor-Supplied Synonyms

2-Nitrobenzyl chloride, 612-23-7, O-NITROBENZYL CHLORIDE, 1-(Chloromethyl)-2-nitrobenzene, alpha-Chloro-2-nitrotoluene, Benzene, 1-(chloromethyl)-2-nitro-, 2-Nitrobenzylchloride, alpha-Chloro-o-nitrotoluene, CCRIS 2323, Toluene, alpha-chloro-o-nitro-, BXCBUWKTXLWPSB-UHFFFAOYSA-N, Toluene, .alpha.-chloro-o-nitro-, EINECS 210-300-5, NSC 66500, BRN 0388396, ST50214154, o-nitrobenzylchloride, 2-nitro-benzylchlorid, 2-nitro-benzylchloride, 2-nitrobenzyl-chloride, ACMC-1AXME, AC1L1YFU, AC1Q1WWN, DSSTox_CID_5744, UNII-HB8U484NPM, DSSTox_RID_77905, HB8U484NPM, 2-(Chloromethyl)nitrobenzene, DSSTox_GSID_25744, SCHEMBL69613, KSC126I6P, MLS002454429, .alpha.-Chloro-o-nitrotoluene, Benzene, (chloromethyl)nitro-, 107336_ALDRICH, CHEMBL175193, 2-(chloromethyl)-1-nitrobenzene, 73180_FLUKA, CTK0C6467, MolPort-000-871-768, 1-(Chloromethyl) -2-nitrobenzene, 1-(chloromethyl)-2-nitro-benzene, HMS3039H12, ACN-S004617, EBD54455, NSC66500, Tox21_200821, ANW-33732, NSC-66500, ZINC00559406, AKOS000294914, LS-1463, NCGC00091732-01, NCGC00091732-02, NCGC00091732-03, NCGC00258375-01, AJ-23484, AK161877, AN-46495, CAS-612-23-7, KB-25720, R601, SC-65625, SMR001372019, ZB014424, AB0057476, DB-000162, RT-000958, AM20040856, Benzene, 1-(chloromethyl)-2-nitro- (9CI), FT-0613188, N0182, ST24037586, A24708, 52153-EP2308844A2, 52153-EP2308845A2, 52153-EP2308846A2, I01-7388, 3B3-013239, 1-(Chloromethyl) -2-nitrobenzene;1-(chloromethyl)-2-nitro-benzen, InChI=1/C7H6ClNO2/c8-5-6-3-1-2-4-7(6)9(10)11/h1-4H,5H, 115361-26-7

Removed Synonyms

Chloro-o-nitrotoluene, CID11921, 4-05-00-00854 (Beilstein Handbook Reference), C05753000, C057530000

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