Preparation of 2-chloroethyl propyl ketone
Alternative Names: 1-chloro-3-hexanone; 3-Hexanone, 1-chloro-; 1-CHLOROHEXAN-3-ONE;
158 g of powdered aluminium chloride are added in 30 min, with stirring, to 126 g of butyryl chloride cooled in ice-salt, and stirring is continued for 50 min thereafter. Then dry ethylene is led in to the mixture at 20° C until the weight increase amounts to 33 g and the reaction mixture is stirred for a further 30 min at 20° C. Working up is by addition of ice, extraction with chloroform, and distillation, giving an 80 % yield of 2-chloroethyl propyl ketone, b.p. 67-68°/11 mm.
J. Chem. Soc, 1946, 52.