Synthesis of 2-bromopropionyl bromide

Preparation of 2-bromopropionyl bromide

To the round bottom flask fitted with dropping funnel and reflux condenser 50 g of dry propionic acid and 7.6 g of dry amorphous phosphorus are added. From the dropping funnel slowly 66.7 g of bromine are added. When the first portion of bromine is added the mixture is warmed to 40-50° C, and an additional portion of 100 g of bromine from dropping funnel are slowly added. The reaction proceeds rapidly and it is complete by gentle refluxing for 2 hours. 2-Bromopropionyl bromide is distilled at 154° C under atmospheric pressure, yielding 75-80 %.

An advanced laboratory manual of organic chemistry, M. Heidelberger, 20, 1923


2-bromopropanoyl bromide



InChI Key


Canonical SMILES


Depositor-Supplied Synonyms

2-Bromopropionyl bromide, 2-Bromopropanoyl bromide, 563-76-8, Propanoyl bromide, 2-bromo-, 2-bromopropionylbromide, 2-bromo propionyl bromide, .alpha.-Bromopropionyl bromide, ILLHORFDXDLILE-UHFFFAOYSA-N, a-bromopropionyl bromide, AC1L2WJD, AC1Q1LDY, 2-bromo-propionyl bromide, alpha-bromopropionylbromide, ACMC-209ls3, alpha-Bromopropionyl bromide, 2-Bromopropanoyl bromide #, SCHEMBL35246, KSC491C4L, (RS)-2-bromopropanoyl bromide, 249785_ALDRICH, 18210_FLUKA, CTK3J1145, ILLHORFDXDLILE-UHFFFAOYSA-, MolPort-001-770-243, EINECS 209-261-7, ANW-32497, STL302038, AKOS009157375, MCULE-2400047844, NE10008, RP26938, RTR-019798, AN-45950, L215, SC-16030, KB-169143, TR-019798, B0649, EN300-36267, 3B4-0619, I14-9611, InChI=1/C3H4Br2O/c1-2(4)3(5)6/h2H,1H3

Removed Synonyms

CID79047, 95673-15-7

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