Synthesis of 1,2-dichloro-2-fluoropropane

Preparation of 1,2-dichloro-2-fluoropropane

500 g of 1,2-dichloro-2-propene and 90 g of anhydrous HF are weighed into a 2-1 steel bomb cooled in dry ice. The bomb is closed with a screwed-down lid carrying a manometer and valve and is heated for 18 h in a water-bath at 50° C. The bomb is then cooled in dry ice, the valve is opened, the lid unscrewed, the reaction mixture is poured on ice and neutralized with dilute sodium hydroxide solution, and the organic layer is separated and distilled in steam. The 450 g of crude product are dried over anhydrous calcium chloride and distilled through a column, giving about 200 g each of 1,2-dichloro-2-fluoropropane, b.p. 85-90° C, and a second fraction, b.p. 90-94° C. The latter was treated again with HF as above and gave a further 75 g of  1,2-dichloro-2-fluoropropane.

Fluorine Chemistry, by J. H. Simons, (Academic Press), 1954, Vol. 2, pp. 340.





InChI Key


Canonical SMILES


Depositor-Supplied Synonyms

1,2-Dichloro-2-fluoropropane, 420-97-3, Propane,1,2-dichloro-2-fluoro-, Propane, 1,2-dichloro-2-fluoro-, 1,2-bis(chloranyl)-2-fluoranyl-propane, HCFC-261, AC1L2RAW, AC1Q3TTF, SCHEMBL1992061, 1,2-Dichloro-2-fluoro propane, CTK4I5704, MolPort-001-773-676, OTKOPXLUNRNYCD-UHFFFAOYSA-N, KST-1B4331, EINECS 206-999-1, AR-1B5742, SBB085778, AKOS006229026, VZ20429, KB-10097, OR000630, OR089505, DB-050843, FT-0606376, FT-0645629, A825759, A826772, 3B3-007747, 1,2-DICHLORO-2-FLUOROPROPANE (HCFC-216BA), TECH

Removed Synonyms

Dichlorofluoropropane, CID101669, 453-17-8, 420-99-5

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