Synthesis of 2-hexanone

Preparation of 2-hexanone

Preparation of 2-hexanone

Preparation of 2-hexanone

A mixture of 1 g of mercury(II) sulfate, 1 g of concentrated sulfuric acid, and 150 g of 70% methanol (or 150 g of 70% acetone or 50 g of 60% acetic acid) is warmed to 60° in a 500-ml three-necked flask fitted with a stirrer, dropping funnel, and reflux condenser. 1-Hexyne (41.0 g, 0.5 mole) is dropped in, with stirring, within 1 hour. The mixture is stirred for a further 3 hours at the temperature stated, then cooled, and worked up. The methanol (or acetone) is distilled off and the 2-hexanone is salted out from the residue by solid sodium chloride. The ketone layer is separated, washed, neutralized, dried over calcium chloride, and distilled, giving 78.8% of 2-hexanone, b.p. 120°. When acetic acid has been used as solvent, it is neutralized with sodium carbonate solution before working up as above.

J. Amer. Chem. Soc, 60, 718 (1938).





InChI Key


Canonical SMILES


MeSH Synonyms

2 Hexanone, 2-Hexanone, Butylmethyl Ketone, Hexan 2 one, Hexan-2-one, Ketone, Butylmethyl, Ketone, Methyl n-Butyl, Methyl n Butyl Ketone, Methyl n-Butyl Ketone, n-Butyl Ketone, Methyl

Depositor-Supplied Synonyms

2-HEXANONE, Hexan-2-one, 591-78-6, Hexanone, Propylacetone, n-Butyl methyl ketone, Butyl methyl ketone, 2-Oxohexane, Methyl N-butyl ketone, Methyl butyl ketone, Hexanone-2, Ketone, butyl methyl, MNBK, 2-Hexanone Methyl n-butyl ketone, n-C4H9COCH3, HSDB 543, QQZOPKMRPOGIEB-UHFFFAOYSA-N, EINECS 209-731-1, MBK, BRN 1737676, 30637-87-7, hexane one, 2-hexanal, hexane-2-one, 2 -hexanone, Butanone, ethyl-, methyl-4-pentanone, MBK|, ACMC-209mb7, UNII-6QDY60NH6N, AC1L1XO0, 6QDY60NH6N, SCHEMBL43282, 47733U_SUPELCO, KSC223M0P, 2-hexanone_GurudeebanSatyavani, 103004_ALDRICH, AC1Q2V81, CCRIS 8810, CHEMBL195861, DTXSID0022068, 02473_FLUKA, CHEBI:89206, CTK1C3607, HMDB05842, BB_SC-6917, 103004_SIAL, STR04219, ZINC2034597, 7510AF, ANW-33185, BBL011434, LMFA12000048, MFCD00009482, SBB061262, STL146542, ZINC02034597, AKOS000118992, MCULE-3554390184, RP18709, TRA-0205942, AN-21543, CJ-07522, CJ-31901, LP027947, LS-75436, OR010868, OR290906, DB-003271, KB-171983, TR-020540, FT-0612492, ST51047300, 26072-EP2287159A1, 26072-EP2314558A1, 74377-EP2269986A1, 74377-EP2281821A1, 74377-EP2308857A1, 74377-EP2380568A1, 74378-EP2308857A1, 4-01-00-03298 (Beilstein Handbook Reference), A801945, A832195, I14-4180, F0001-1552, InChI=1/C6H12O/c1-3-4-5-6(2)7/h3-5H2,1-2H

Removed Synonyms

Volatile oil, GC-Ms analysis, 2 Hexanone, Butylmethyl Ketone, Hexan 2 one, Ketone, Butylmethyl, Citrullus colocynthis, Methyl n Butyl Ketone, Ketone, Methyl n-Butyl, n-Butyl Ketone, Methyl, C6H12O, MolPort-001-759-240, CID11583, RTR-020540, H0114, D008742, 108-94-1

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