Synthesis of 1,2-phenylene phosphorotrichloridite

Preparation of 1,2-phenylene phosphorotrichloridite

Chlorine is passed into a stirred and ice-cooled solution containing 15g of 2-chloro-1,3,2-benzodioxaphosphole in 40 ml of dry carbon tetrachloride until gaseous chlorine can be recognized in the condenser by its color. Vacuum-distillation yields a 94% yield or 19.8 g of the 1,2-phenylene phosphorotrichloridite, m.p. 61-62°, b.p. 132-135°/13 mm.

Preparation of 1,2-phenylene phosphorotrichloridite from 2-chloro-1,3,2-benzodioxaphosphole 2-oxide

Preparation of 1,2-phenylene phosphorotrichloridite from 2-chloro-1,3,2-benzodioxaphosphole 2-oxide

1,2-phenylene phosphorotrichloridite is olso prepared by adding 20 g of phosphorus pentachloride 15 g of 2-chloro-1,3,2-benzodioxaphosphole 2-oxide  in 60 ml of benzene. Boiling for 90 min under reflux and subsequent distillation in a vacuum gives an 88% yield (17 g) of the 1,2-phenylene phosphorotrichloridite.

H. Gross, J. Gloede, Chem. Ber., 96, 1387 (1963)





InChI Key


Canonical SMILES


Depositor-Supplied Synonyms

2007-97-8, 1,2-Phenylene phosphorotrichloridite, Catechylphosphorotrichloride, 2,2,2-trichloro-1,3,2|E5-benzodioxaphospholato, F9995-0148, 2,2,2-Trichloro-2,2-dihydro-1,3,2-benzodioxaphosphole, EINECS 217-913-7, AC1L2MQJ, AC1Q3VIJ, SCHEMBL356873, AR-1D0315, MFCD00014578, AKOS015957644, ZINC100031866, MCULE-3730666911, HE019693, HE183699, KB-48703, FT-0609025, 2,2,2-trichloro-1,3,2lambda5-benzodioxaphosphole, 2,2,2-TRICHLORO-1,3,2??-BENZODIOXAPHOSPHOLE, 1,3,2-Benzodioxaphosphole, 2,2,2-trichloro-2,2-dihydro-, 2,2,2-trichloro-2lambda5-benzo[d][1,3,2]dioxaphosphole

Removed Synonyms

2,2,2-trichloro-1,3,2, MolPort-006-113-855, CID74825, 2050-54-6

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