Synthesis of nitric oxide

Preparation of nitric oxide

A Woulff’s bottle, fitted with a funnel and delivery tube, is filled loosely with strips of copper, and then 1/3 with a cold saturated solution of sodium nitrate. Strong sulfuric acid is added, according to the amount of gas required. The evolution of gas is very regular, and may be kept up for hours.

Nitric oxide may also be prepared from a mixture of solutions of potassium ferrocyanide and potassium nitrite added gradually from a stoppered funnel to a flask containing acetic acid. During the addition the contents of the flask must be vigorously shaken during the operation.

By another method a strong solution of sodium nitrite is added to a solution of ferrous chloride or sulfate in hydrochloric acid.

Laboratory manual of inorganic preparations, by H. T. Vulte, 25-27, 1895


nitric oxide



InChI Key


Canonical SMILES


MeSH Synonyms

Endogenous Nitrate Vasodilator, Endothelium-Derived Nitric Oxide, Mononitrogen Monoxide, Monoxide, Mononitrogen, Monoxide, Nitrogen, Nitrate Vasodilator, Endogenous, Nitric Oxide, Nitric Oxide, Endothelium Derived, Nitric Oxide, Endothelium-Derived, Nitrogen Monoxide, Oxide, Nitric, Vasodilator, Endogenous Nitrate

Depositor-Supplied Synonyms

nitric oxide, Mononitrogen monoxide, INOmax, nitrogen monooxide, nitrosyl, oxoazanyl, oxyde azotique, oxido nitrico, Stickstoffmonoxid, monoxyde d’azote, oxidonitrogen(.), 10102-43-9, Nitric oxide trimer, EDRF, monoxido de nitrogeno, Stickstoff(II)-oxid, Nitric oxide (JAN), INOmax (TN), oxido de nitrogeno(II), AC1L3QHF, UNII-31C4KY9ESH, [NO], 295566_ALDRICH, CHEMBL1200689, CHEBI:16480, (.)NO, endothelium-derived relaxing factor, NO(.), OHM 11771, (NO)(.), DB00435, C00533, D00074, Oxide, Nitric, Monoxide, Nitrogen, Monoxide, Mononitrogen, Endogenous Nitrate Vasodilator, Nitrate Vasodilator, Endogenous, Vasodilator, Endogenous Nitrate, Endothelium-Derived Nitric Oxide, Nitric Oxide, Endothelium Derived, Nitric Oxide, Endothelium-Derived, Nitrogen(II) oxide, CID145068, NITRIC-OXIDE, 31C4KY9ESH, D009569, CID945, CHEMBL1234765, CTK0H7679, MolPort-003-929-452, DAP001056

Removed Synonyms

nitrogen monoxide, Nitrogen oxide, nitrogen protoxide, Nitrosyl radical, Stickmonoxyd, Nitroxyl, oxyde nitrique, Amidogen, oxo-, Nitrosyl hydride, Bioxyde d’azote, Nitrite Ion, Nitroxide radical, Nitrogen oxide (NO), HYDROXYAMINE, Stickmonoxyd [German], RCRA waste number P076, Oxyde nitrique [French], AC1L1ADQ, Bioxyde d’azote [French], RCRA waste no. P076, AC1Q6QZ0, Nitrosyl hydride ((NO)H), CCRIS 4319, HSDB 1246, Nitric oxide 10% by volume or more, UN 1660, EINECS 233-271-0, AR-1K7463, UN1660, LS-7547, LS-192158, Nitric oxide, compressed [UN1660] [Poison gas], Nitric oxide, compressed [UN1660] [Poison gas], NO, 11104-93-1, 14332-28-6, 51005-20-0, 51005-21-1, 53851-19-7, 90452-29-2, HNO, HOA, NMO, NO2

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