Synthesis of heptanenitrile

Preparation of heptanenitrile

Preparation of heptanenitrile

Preparation of heptanenitrile

30 g of dry sodium cyanide (dried at 110º C overnight a) are mixed with 150 ml of dry dimethyl sulfoxide. The mixture is added to the flask fitted with a stirrer, reflux condenser, dropping funnel, and thermometer. The thick reaction slurry is heated to 90º C and the heating then  is stopped.  0.5 mole of 1-chlorohexane is slowly added to the stirred mixture causing the temperature to increase immediately. The rate of addition is such that the temperature of the reaction did not go above about 160º C. After all the 1-chlorohexane is added the mixture is stirred for additional 10 min. more, or until the temperature dropped below 50º C. After the reaction is complete the mixture is poured into water and the product extracted several times with chloroform or ethyl ether. The extract is washed several times with saturated sodium chloride solution, dried over calcium chloride, and the heptanenitrile is distilled at 96-97º C/50mmHg yielding 91% of the final product.

J. Org. Chem., 1960, 25 (2), pp 257–258

IUPAC Name

heptanenitrile

InChI

InChI=1S/C7H13N/c1-2-3-4-5-6-7-8/h2-6H2,1H3

InChI Key

SDAXRHHPNYTELL-UHFFFAOYSA-N

Canonical SMILES

CCCCCCC#N

Depositor-Supplied Synonyms

HEPTANENITRILE, Heptanonitrile, Hexyl cyanide, Enanthonitrile, 629-08-3, 1-Cyanohexane, 1-Heptanonitrile, n-Heptanenitrile, Heptane-1-nitrile, UNII-UA4Z3QT98A, SDAXRHHPNYTELL-UHFFFAOYSA-N, NSC 2172, EINECS 211-071-4, SBB060052, 1885-40-1, AI3-28301, Heptane nitrile, Heptyl nitrile, n-Hexyl cyanide, n-Heptanoic acid nitrile, AC1L1ZGC, DSSTox_CID_1599, ACMC-209na6, DSSTox_RID_76226, UA4Z3QT98A, DSSTox_GSID_21599, SCHEMBL130441, 404896_ALDRICH, CHEMBL1231869, CTK2F4895, SDAXRHHPNYTELL-UHFFFAOYSA-, NSC2172, NSC-2172, ZINC1577185, Tox21_200526, 7774AF, ANW-34444, AKOS009157585, MCULE-7652123212, NCGC00248675-01, NCGC00258080-01, AK176364, AN-46924, CAS-629-08-3, LP078721, OR012237, DB-054326, LS-195273, TC-123189, TL8004314, ST51046305, 3B3-051671, I14-112485, InChI=1/C7H13N/c1-2-3-4-5-6-7-8/h2-6H2,1H3, 73833-76-8, CNX

Removed Synonyms

C7H13N, CID12372, H0883

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