Synthesis of dimephosphon

Preparation of dimephosphon

Preparation of dimephosphon

Preparation of dimephosphon

To a mixture of  110 gr dimethylphospite (1 mol)  and 110 gr of mesityle oxide was slowly  added 30% solution of 0.3 mol sodium methylate in methanol at room temperature while cooling. After this mixture was mixed overnight and methanol was distilled off. The obtained residue was distilled  in vacuum. The fraction boiling at 135-140 C/20 mm was collected and in order to obtain pure dimephosphon re-distilled one more time. Yield 124 gr (61%). Purity 98%. Light yellow liquid.

Synthesis submitted and performed by Rinat Miftakhov.

IUPAC Name

4-dimethoxyphosphoryl-4-methylpentan-2-one

InChI

InChI=1S/C8H17O4P/c1-7(9)6-8(2,3)13(10,11-4)12-5/h6H2,1-5H3

InChI Key

MOMJYWJXUNIBGJ-UHFFFAOYSA-N

Canonical SMILES

CC(=O)CC(C)(C)P(=O)(OC)OC

MeSH Synonyms

(1,1-dimethyl-3-oxobutyl)phosphonic acid dimethyl ester, dimephosphon

Depositor-Supplied Synonyms

dimephosphon, (1,1-Dimethyl-3-oxobutyl)phosphonic acid dimethyl ester, dimethyl(2-methyl-4-oxopentan-2-yl)phosphonate, Phosphonic acid, (1,1-dimethyl-3-oxobutyl)-, dimethyl ester, 14394-26-4, Mitsefosfon, AC1Q6SDO, AC1L3U4S, UNII-136CQC28US, 136CQC28US, SCHEMBL8350477, CTK3E9195, ZINC5159502, AR-1I5740, OR221075, 4-dimethoxyphosphoryl-4-methylpentan-2-one, LS-106582

Removed Synonyms

C8H17O4P, CID122179, 86003-41-0, 92431-51-1

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