Synthesis of chalcone

Preparation of chalcone

Alternative Names: Chalcone; Trans-Chalcone; (E)-Chalcone; Benzalacetophenone; Benzylideneacetophenone; Chalkone;

Preparation of chalcone

Preparation of chalcone

2.1 g of benzaldehyde and 2.4 g of acetophenone are dissolved in 20 g of alcohol, 2 g of 10% sodium hydroxide solution are added, and the whole allowed to stand for 24 hours. The precipitate is recrystallized from ligroin. Yield theoretical 4 g. Colorless crystals; m.p. 57-58° C; b.p. 346° C.

Systematic organic chemistry, by W. M. Cumming, 99-100, 1937.

IUPAC Name

(E)-1,3-diphenylprop-2-en-1-one

InChI

InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+

InChI Key

DQFBYFPFKXHELB-VAWYXSNFSA-N

Canonical SMILES

C1=CC=C(C=C1)C=CC(=O)C2=CC=CC=C2

Isomeric SMILES

C1=CC=C(C=C1)/C=C/C(=O)C2=CC=CC=C2

MeSH Synonyms

1,3 Diphenyl 2 Propen 1 One, 1,3-Diphenyl-2-Propen-1-One, Benzalacetophenone, Benzylideneacetophenone, Chalcone, Chalkone

Depositor-Supplied Synonyms

Chalcone, trans-Chalcone, (E)-Chalcone, Benzalacetophenone, Benzylideneacetophenone, Chalkone, Phenyl styryl ketone, 614-47-1, Cinnamophenone, 2-Benzalacetophenone, 94-41-7, 1,3-DIPHENYL-2-PROPEN-1-ONE, 2-Benzylideneacetophenone, Styryl phenyl ketone, 3-Phenylacrylophenone, trans-Benzalacetophenone, beta-Benzoylstyrene, 2-Propen-1-one, 1,3-diphenyl-, 1-Benzoyl-2-phenylethene, Benzylidenecetophenone, (2E)-1,3-diphenylprop-2-en-1-one, 1-Phenyl-2-benzoylethylene, 1,3-Diphenylpropenone, beta-Phenylacrylophenone, (E)-1,3-diphenylprop-2-en-1-one, 1-Benzoyl-1-phenylethene, Acrylophenone, 3-phenyl-, Phenyl trans-styryl ketone, (E)-Benzylideneacetophenone, 1,3-Diphenyl-2-propenone, alpha-Benzylideneacetophenone, Phenyl 2-phenylvinyl ketone, trans-Benzylideneacetophenone, (E)-1,3-Diphenyl-2-propen-1-one, 1,3-Diphenyl-1-propen-3-one, 1,3-diphenylprop-2-en-1-one, .beta.-Benzoylstyrene, Benzylidene acetophenone, 2-Propen-1-one, 1,3-diphenyl-, (E)-, substituted chalcone, 5j, NSC 26612, .beta.-Phenylacrylophenone, 1-Benzoyl-2-phenylethylene, (2E)-1,3-Diphenyl-2-propen-1-one, CHEMBL7976, UNII-5S5A2Q39HX, .alpha.-Benzylideneacetophenone, CCRIS 2213, CCRIS 3778, CHEBI:48965, DQFBYFPFKXHELB-VAWYXSNFSA-N, Phenyl (E)-2-phenylethenyl ketone, EINECS 202-330-2, EINECS 210-383-8, phenyl (E)–2-phenylethenyl ketone, benzylidenacetophenone, (E)-1,3-DIPHENYL-PROPENONE, AI3-00946, WLN: RV1U1R, .omega.-Benzylideneacetophenone, Chalcone methoxyamine, DQFBYFPFKXHELB-UHFFFAOYSA-N, Chalkon, b-Benzoylstyrene, 1,3 Diphenyl 2 Propen 1 One, Chalcone 1, phenylstyryl ketone, b-Phenylacrylophenone, Chalcone, 13, 3-phenyl-Acrylophenone, AC1LCUWN, a-Benzylideneacetophenone, AC1Q5BJD, bmse000704, SCHEMBL27580, chalcone (ACD/Name 4.0), MLS000069600, 11970_ALDRICH, BIDD:ER0232, Bio-0784, 136123_ALDRICH, 5S5A2Q39HX, cid_637760, 11970_FLUKA, BDBM29143, CHEBI:27618, HMDB03066, NSC4523, 1, 3-Diphenyl-1-propen-3-one, MolPort-000-513-959, MolPort-004-963-007, HMS2235P17, NSC-4523, NSC26612, STR06550, 9216AB, BBL010497, DNC009415, NSC-26612, NSC167107, SBB058654, STK257430, ZINC38139289, AKOS001041518, AKOS025310645, (E)-1,3-diphenyl-prop-2-en-1-one, 2-Propen-1-one,3-diphenyl-, (E)-, NE10263, NSC-167107, RP26425, RTR-038514, NCGC00018232-03, (E)-3-phenyl-1-phenylprop-2-en-1-one, AC-16892, AJ-94562, AK-93565, AN-46542, CJ-19140, I420, KB-02521, LS-52891, OR020083, OR298056, SC-46378, SMR000059029, AB1011801, KB-119874, LS-123899, RT-003040, TL8005961, TR-038514, FT-0622849, FT-0623579, ST24020690, ST50164547, EN300-16057, C01484, C15589, A833233, AE-641/00372002, I14-5903, J-200119, 3B3-033052, I14-100778, 5173133B-0B1C-46FB-8DFF-976669EE9D5B, 1081515-13-0

Removed Synonyms

2-Propen-1-one,3-diphenyl-, c0071, CID637760, D002599, 2-(Benzylidene)acetophenone; 1,3-Diphenyl-2-propen-1-one; trans-Chalcone; Chalcone; Phenyl Styryl Ketone; 2-Benzylideneacetophenone; 2-Benzalacetophenone

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