Synthesis of 6-amino-1,3-dimethyluracil

Preparation of 6-amino-1,3-dimethyluracil

Preparation of 6-amino-1,3-dimethyluracil

Preparation of 6-amino-1,3-dimethyluracil

20 g of sodium amide 20 g and dry dimethylurea are thoroughly mixed, and treated with 20 g of xylene. With efficient stirring and good cooling are added 20 g of ethyl cyanoacetate. After the main reaction is over, the mixture is heated for several hours at 100-120° C. After cooling, the product is carefully treated with water, the xylene removed, and the 6-amino-1,3-dimethyluracil precipitated with acid. Instead of sodium amide, sodium in absolute alcohol may be used, or sodium in xylene.

Organic medical chemicals, by M. Barrowliff, 237, 1921

IUPAC Name

6-amino-1,3-dimethylpyrimidine-2,4-dione

InChI

InChI=1S/C6H9N3O2/c1-8-4(7)3-5(10)9(2)6(8)11/h3H,7H2,1-2H3

InChI Key

VFGRNTYELNYSKJ-UHFFFAOYSA-N

Canonical SMILES

CN1C(=CC(=O)N(C1=O)C)N

MeSH Synonyms

6-amino-1,3-dimethyl uracil, 6-amino-1,3-dimethyluracil

Depositor-Supplied Synonyms

6-Amino-1,3-dimethyluracil, 6642-31-5, 6-amino-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, 1,3-Dimethyl-6-amino-uracil, 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione, Uracil, 6-amino-1,3-dimethyl-, 2,4(1H,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-, 6-Amino-1,3-dimethyl uracil, VFGRNTYELNYSKJ-UHFFFAOYSA-N, EINECS 229-662-0, 6-Amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione, NSC 15492, BRN 0144390, 6-amino-1,3-dimethylpyrimidine-2,4-dione, AI3-52449, 6-amino-1,3-dimethyl-1,3-dihydropyrimidine-2,4-dione, 6-Amino-1,3-dimethyluracil inverted exclamation mark cent6-Amino-1,3-dimethyl-2,4(1h,3h)-dione, NSC15492, PubChem22145, ACMC-209nvi, Oprea1_258982, SCHEMBL23857, 4-Amino-1,3-dimethyluracil, A52153_ALDRICH, 6-amino-N,N’-dimethyluracil, KSC496E5J, AC1L30Q6, CTK3J6254, MolPort-000-145-988, BB_SC-3461, HMS1760O20, ACN-S001264, ANW-35212, BBL008946, CA0190, KM1014, NSC-15492, SBB004028, STK711155, ZINC00105224, AKOS000119420, AKOS015923159, MCULE-8108343390, RP17865, AJ-11170, AK114617, AN-14353, CJ-00762, H342, ZB003550, 6-amino-1,3-dimethyl-2,4-dioxopyrimidine, LS-158544, 6-amino-1,3-dimethyl-pyrimidine-2,4-dione, FT-0620900, ST45024948, 6-azanyl-1,3-dimethyl-pyrimidine-2,4-dione, 2,3H)-Pyrimidinedione, 6-amino-1,3-dimethyl-, 6-amino-1,3-dimethyl-1H-pyrimidine-2,4-dione, 5-25-15-00389 (Beilstein Handbook Reference), A835462, AB-323/25048015, I14-0657, 6-Amino-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione #, 3B3-029805, T0518-5994

Removed Synonyms

Uracil,3-dimethyl-, ?6-Amino-1,3-dimethyluracil, CID81152, A1420, 4-Amino-1,3-dimethyl-2,6-dihydroxypyrimidine

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