Preparation of 2,4,6-tribromoaniline
For the bromination of aniline 500 ml Buchner flask A is fitted with a stopper through which passes a glass delivery tube B reaching nearly to the bottom of Buchner flask A. The glass delivery tube B is connected to the side-arm of a distillation-flask C. A narrow glass tube D is then fitted within 2-3 cm of the bottom of distillation-flask C. When glass apparatus is assembled 4 ml of aniline dissolved in 10 ml of dilute hydrochloric acid and diluted with 200 ml of water are placed in Buchner flask A.
6.4 ml (or 20.5 g) of bromine is placed in distillation-flask C, which contains 40-50 ml of cold water. The glass tube D is adjusted until it nearly touches the surface of the bromine, and through Buchner flask A a suction of air with a water-pump is started, so that a steady stream of bromine vapor is carried over from distillation flask C into Buchner flask A. Soon the grayish-white 2,4,6-tribromoaniline begins to separate. The reaction mixture in Buchner flask A is shaken from time to time and when water in C becomes almost colorless the bromination reaction is complete. The obtained 2,4,6-tribromoaniline the reaction mixture is filtered, wash well with water, and recrystallized with small amount of activated charcoal from ethanol. 2,4,6-Tribromoaniline is obtained as colorless crystals, which melt at 120° C. Yield of final product is 8.5 g.
Practical organic chemistry, by F. G. Mann, 165-166, 1960
2,4,6-TRIBROMOANILINE, 147-82-0, s-Tribromoaniline, 2,4,6-Tribromophenylamine, Benzenamine, 2,4,6-tribromo-, sym-Tribromoaniline, 2,4,6-Tribromobenzenamine, USAF DO-43, Aniline, 2,4,6-tribromo-, Aniline tribromide, TRIBROMOANILINE, HSDB 2689, GVPODVKBTHCGFU-UHFFFAOYSA-N, NSC 2216, EINECS 205-700-1, BRN 2209258, AI3-21064, 2,6-Tribromoaniline, PubChem3216, 2,4,6-Tribromoanine, 2,4,6-Tribomoaniline, ACMC-209czc, 2,6-Tribromophenylamine, Aniline,4,6-tribromo-, UNII-0C2N8WIL3B, WLN: ZR BE DE FE, AC1L1S2P, Benzenamine,4,6-tribromo-, 0C2N8WIL3B, SCHEMBL29210, KSC497G6R, 2,4,6-tris(bromanyl)aniline, 163694_ALDRICH, AC1Q25L9, CTK3J7368, TIMTEC-BB SBB040457, (2,4,6-tribromo-phenyl)-amine, NSC2216, AKOS B028948, MolPort-000-158-728, HMS1577N09, NSC-2216, AKOS BBS-00003575, ANW-21094, AR-1D3032, SBB040457, STK084272, ZINC00262690, AKOS000118846, 2,4,6-TRIBROMOANILINE, PRACT, AN-1147, AS03653, LS11450, MCULE-7546391388, NE10500, AC-10671, AJ-18505, AK105944, KB-82592, LS-20001, Q258, ZB009945, DB-023746, RT-003805, FT-0609838, ST24038590, ST50213735, 4-12-00-01538 (Beilstein Handbook Reference), A808698, AE-641/00784057, S01-0544, T7105950, 3B3-030283, InChI=1/C6H4Br3N/c7-3-1-4(8)6(10)5(9)2-3/h1-2H,10H
CID8986, T0345, T1088, T1122, 15019-72-4, 52628-37-2