Synthesis of 2-bromobenzoic acid

Preparation of 2-bromobenzoic acid

Preparation of 2-bromobenzoic acid

Preparation of 2-bromobenzoic acid

35 g of crystallized copper sulfate, 100 g of sodium bromide, and 30 g of copper turnings are boiled under a reflux condenser with 300 ml of water and 33 g of concentrated sulfuric acid until the solution is almost decolorized. 40 g of anthranilic acid are then added and the solution is allowed to cool with ice-water to 0° C. Concentrated, aqueous solution of 21 g of sodium nitrite is slowly added and during the addition the temperature should not exceed 5° C. When all the sodium nitrite has been added the reaction mixture is allowed to stand overnight at the room temperature. The precipitated 2-bromobenzoic acid is then collected, washed with cold water, and recrystallized from water yielding 82 % of long colorless needles melting at 147-150° C.

Preparation of organic compounds, E. de. Barry Barnett, 77, 1912

IUPAC Name

2-bromobenzoic acid

InChI

InChI=1S/C7H5BrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10)

InChI Key

XRXMNWGCKISMOH-UHFFFAOYSA-N

Canonical SMILES

C1=CC=C(C(=C1)C(=O)O)Br

MeSH Synonyms

2-bromobenzoic acid

Depositor-Supplied Synonyms

2-BROMOBENZOIC ACID, o-Bromobenzoic acid, 88-65-3, Benzoic acid, 2-bromo-, Benzoic acid, o-bromo-, 2-Bromo-benzoic acid, Bromobenzoic acid, Benzoic acid, bromo-, UNII-AZ789TZS4L, XRXMNWGCKISMOH-UHFFFAOYSA-N, NSC 6976, EINECS 201-848-6, SBB058412, BRN 0971266, AI3-03699, 25638-04-4, o-bromobenzoicacid, o-bromo benzoic acid, 2-bromo benzoic acid, PubChem3739, ACMC-1BKGP, AC1L1NN1, AC1Q5U5E, AZ789TZS4L, SCHEMBL49806, KSC202O4D, ORTHO-BROMOBENZOIC ACID, 137677_ALDRICH, AC1Q721X, ARONIS008730, CHEMBL115950, RARECHEM AL BO 0014, 16320_FLUKA, CTK1A2741, NSC6976, ATTERCOP-CHM AT111657, MolPort-000-151-734, NSC-6976, STR04298, ANW-39124, AR-1D9583, BBL025932, LABOTEST-BB LT01143292, LABOTEST-BB LT03329502, LABOTEST-BB LT03330984, LABOTEST-BB LT03408090, STK399786, AKOS000119014, AB00223, AC-3084, AM81263, AS00760, LS10336, MCULE-3239222085, PS-5299, RP25821, RP25824, RTR-027891, AJ-16268, AK-77301, AN-13329, KB-21678, LS-36194, SC-07180, TL806152, AB1003393, DB-020710, ST2409734, TR-027891, B0552, FT-0600392, ST45045473, M-6066, AB01330856-02, AE-641/00396046, I01-0406, T5883849, 3B3-034896, InChI=1/C7H5BrO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4H,(H,9,10

Removed Synonyms

2-Bromobenzoate, null, Telmisartan, CID6940, 4-27-00-07537 (Beilstein Handbook Reference), 144701-48-4, 94-41-7

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