Preparation of 2-bromo-3-methylbutanoyl bromide
In a round bottom 500 ml flask 88 g of isobutyric acid and 10 g of red phosphorus are placed. The flask was connected to a reflux condenser and a 250 ml dropping funnel. The funnel is charged with 352 g of bromine. The flask was cooled in a water bath while slowly bromine was dropwise added. The reaction is exothermic, so the rate of reaction is controlled by addition of bromine. After addition of all bromine that lasts about two hours, the flask is heated for 1 hour in a boiling water bath. Then, the reflux condenser is replaced by distillation head and distilled any excess of bromine from the reaction mixture. The flask contains crude 2-bromo-3-methylbutanoyl bromide which is purified by distillation.
Препаративная органическая химия, Вульфсон Н.С., 182, 1959 (Preparative organic chemistry, Wolfson N. S., 182, 1959)
2-bromo-3-methylbutanoyl bromide, 26464-05-1, 2-Bromo-3-methylbutyryl bromide, AC1L3KMA, SCHEMBL2852567, CTK4F7939, AC1Q2468, Butanoyl bromide,2-bromo-3-methyl-, EINECS 247-719-8, AR-1D9464, KB-168875, FT-0611575, 3B3-058127