Synthesis of 1-fluorobutane

Preparation of 1-fluorobutane

Preparation of 1-fluorobutane

Preparation of 1-fluorobutane

In a three-necked flask fitted with a stirrer, a dropping funnel, and a Wurtz column connected to a downward Liebig condenser, 37.8 g (0.2 mol) of (2-chloro-1,1,2-trifluoroethyl)diethylamine are placed, to which 14.8 g (0.2 mol) of n-butyl alcohol are added dropwise. The reaction proceeds with the evolution of heat; 1-fluorobutane formed in the reaction distils off from the flask. The product is washed with ice-water, dried over calcium chloride and distilled yielding 10.1 g (75%) of 1-fluorobutane; bp 31.5 °C/731 mm Hg; nD 1.3410 at 20 °C.

Zh. Obshch. Khim. 29, 2159 (1959)

Alternatively 1-fluorobutane could be obtained by the reaction of 1-bromobutane with HgF(Bull. Sci. Acad. R. BelJ. 44, 8 (1934)).

IUPAC Name

1-fluorobutane

InChI

InChI=1S/C4H9F/c1-2-3-4-5/h2-4H2,1H3

InChI Key

FCBJLBCGHCTPAQ-UHFFFAOYSA-N

Canonical SMILES

CCCCF

Depositor-Supplied Synonyms

1-FLUOROBUTANE, Butane, 1-fluoro-, 2366-52-1, Butyl fluoride, sJPHAHIJuP@, 1-fluoranylbutane, AC1L28XL, C4H9F, CTK1A2872, FCBJLBCGHCTPAQ-UHFFFAOYSA-N, MolPort-000-155-551, ZINC2038676, EINECS 219-123-8, 8004AD, PC9870, AKOS006228780, KB-65098, LP045179, OR034959, TR-010973, FT-0607780, A816829, InChI=1/C4H9F/c1-2-3-4-5/h2-4H2,1H, I14-29966

Removed Synonyms

CID16908

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